Haemoglobin Epsilon as a Biomarker for the Molecular Detection of Canine ‎Lymphoma


 Lymphoma is a cancer arising from B or T lymphocytes that are central immune system ‎components. It one of the three most common cancers encountered in canine; ‎lymphoma affects middle-aged to older dogs and usually stems lymphatic tissues, ‎such as lymph nodes, lymphoid tissue, spleen. Despite advance management ‎canine lymphoma, better understanding subtype tumor aggressiveness still ‎crucial for improved clinical diagnosis differentiate malignancy hyperplastic ‎conditions improve decision-making around treating what treatment type use. ‎This study aimed evaluate potential novel biomarker related iron metabolism, ‎embryonic haemoglobin (HBE), early diagnosis. Archived samples combination with ‎prospective collected without lymphoma were used this ‎study retrospective analyses based on same amplified by ‎real-time quantitative polymerase chain reaction. The HBE mRNA was aberrantly expressed ‎in canine cell compared normal node tissue ‎hyperplastic nodes. In conclusion, identified improving ‎diagnosis dogs. Further studies larger sample sizes needed ‎confirm suitability diagnosis.